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We, Tai'an
Zhonghui Plant Biochemical Co.,Ltd. are one of the leading
manufacturer of plant extracts,herb extracts and botanical extracts
in China. We can supply all kinds of standardized extracts and
ratioed extracts.
we enjoy very good reputation in the world market.Hope we can
cooperate with you in near future.
Now we can supply the Tripterygium Wilfordii Extract with the
following specification:
Triptolide 99% Min (HPLC)
Celastrol 10-98% Min (HPLC)
Tripdiolide 98% Min (HPLC)
Wilforlide A 98% Min (HPLC)
Celastrol may be useful to minimize inflammation
in Alzheimer′s
disease (AD). Celastrol is a powerful antioxidant, in an isolated
rat liver assay of lipidperoxidation, celastrol had a 50% inhibitory
cocentration of 7
μM,
equivalent to about 15 times the antioxidant potency of
a-tocopherol.
Scientists have found it to be quite intensely immunosuppressive as
well as anti-inflammatory. Celastrol inhibits macrophage activation,
MHC I and II processing, TNF-alpha, IL1, IL2, and IL6, it may be
developed to be a new anti rheumatoid arthritis(RA) drug.
Recent explorations of the mechanisms of action of triptolide
revealed many properties relevant not only to anti-inflammatory
activity but also to anticancer activity.
Antiproliferative and proapoptotic activity of triptolide has been
shown with many different types of cancer cells in vitro and in vivo
As an immunosuppressive agent with anti-inflammatory and anti-tumor
properties, it is more effective in preventing T cell proliferation
and interferon-g production than FK506. It induces apoptosis in T
cells by activating DEVD cleaving caspases, blocks TNF-amediated
induction of c-IAP1 and c-IAP2 and NF-kB activation.
Triptolide also potentiates the activities of other agents and
therefore may be useful not only as a single compound but also in
combination with other cytotoxic drugs for cancer treatment. Its
succinate salt water-soluble that is converted to triptolide in the
serum, has recently been approved for Phase I clinical trials. |
